No	Publication Year	Document Type	Article Title	Source	Author	DOI
49	2025	Meeting Abstract	Zwitterionic polymer with minimal reactivity against PEG antibodies to enhance the therapeutic effects of cytokine-targeting DNA aptamer	Biomater. Sci., 2025, 13, 1347-1353	Seojung Cho a, Miyuki Hori b, Ryosuke Ueki a, Yutaro Saito a, Yukiko Nagai a, Haruka Iki a, Akira Tsuchiya a, Tomohiro Konno c, Kensuke Owari b, Haishun Piao b, Kazunobu Futami b and Shinsuke Sando	10.1039/D4BM01541J
48	2025	Meeting Abstract	双性イオンポリマーによる医療応用アプタマーの修飾：抗 PEG 抗 体反応性の低減と薬物動態の改善による治療効果の向上	バイオ関連化学シンポジウム	チョ　ソジョン 、堀　美幸 、森本　淳平、齋藤　雄太郎、永井　薫子、尾張健介 朴　海順、二見　和伸、坂田　飛鳥、吉本　敬太郎、鶴田　充生、三好　大輔、山東　信
47	2024	Meeting Abstract	A novel strategy to improve in vivo behavior of DNA aptamers based on the modification with immune-evading polymers	IRT2024	Seojung Cho,a Miyuki Hori,c Ryosuke Ueki,a Yutaro Saito,a Yukiko Nagai,a Haruka Iki,a Akira Tsuchiya,a Tomohiro Konno,d Kensuke Owari,c Haishun Piao,c Kazunobu Futami,c Shinsuke Sando
46	2024	Meeting Abstract	Preclinical development of anti-IFN-γ aptamer TXB-0006 for treating Hunner-type interstitial cystitis	第５回間質性膀胱炎国際専門家会議 (ICICJ) ＆ 2024年 欧州間質性膀胱炎研究会 (ESSIC) 年次総会	Kaori Harada, Kensuke Owari, Yoshiyuki Akiyama, Yi Luo, Miyuki Hori
45	2024	Meeting Abstract	人工塩基導入DNAアプタマーを活用した次世代アフェレシスの開発：妊娠高血圧腎症治療用のアフェレシスカラムの開発を目指して	第９回日本核酸医薬学会	古関　千寿子、堀　美幸、二見　和伸、尾張　健介
44	2024	Meeting Abstract	Effect of Topical Administration of Novel anti-Interferon-Gamma Aptamer in severe Murine Dry Eye model	ARVO2024	Chizuko Koseki
43	2024	Meeting Abstract	Application of Xenoligo® technology platform generating DNA aptamers	Aptamers 2024	Chizuko Koseki
42	2023	Article	Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis	iScience. 2023;26(11):108262.	Yoshiyuki Akiyama, Kaori Harada, Jimpei Miyakawa, Karl J Kreder, Michael A O'Donnell, Maeda Daichi, Hiroto Katoh, Miyuki Hori, Kensuke Owari, Kazunobu Futami, Shumpei Ishikawa, Tetsuo Ushiku, Haruki Kume, Yukio Homma, Yi Luo	10.1016/j.isci.2023.108262
41	2023	Meeting Abstract	マウス重症ドライアイモデルにおける新規抗インターフェロン-γアプタマーの点眼による効果	第43回日本眼薬理学会	堀　美幸、二見 和伸、尾張 健介
40	2023	Meeting Abstract	核酸アプタマーを特異的リガンドとした妊娠高血圧腎症治療用のアフェレシスカラムの開発	第44回日本アフェレシス学会学術大会	古関　千寿子
39	2023	Meeting Abstract	人工塩基導入DNAアプタマーを活用した新しいアフェレシスの開発	第44回日本アフェレシス学会学術大会	古関　千寿子
38	2023	Meeting Abstract	Development of Next Generation Apheresis using Artificial base DNA Aptamer	ISFA2023	Kensuke Owari, Kazunobu Futami, Piao Haishun, Miyuki Hori, Gen Watanabe
37	2023	Meeting Abstract	Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis	The 110th Annual Meeting of The Japanese Urological Association (JUA)	Yoshiyuki Akiyama
36	2022	Meeting Abstract	人工塩基導入 DNA アプタマーを活用した次世代アフェレーシス開発の試み	The 43rd Annual Meeting of the Japanese Society for Apheresis	Kensuke Owari, Miyuki Hori, Kazunobu Futami, Haishun Piao, Gen Watanabe, Chizuko Koseki
35	2022	Meeting Abstract	VEGF165 に対する人工塩基 Ds を含む DNA アプタマーの NMR 解析	The 61st Annual Meeting of the NMR Society of Japan	Tomomi Nagahama, Tatsuhiko Someya, Taiichi Sakamoto
34	2022	Article	Development of a novel aptamer blocking the interaction between the VWF A1 domain and platelet GP Ib for the treatment of arterial thrombosis	Rinsho Ketsueki	Masanori Matsumoto, Kaori Harada	10.11406/rinketsu.63.393
33	2021	Meeting Abstract	Development of novel aptamer blocking the interaction between VWF A1 domain and platelet GP Ib for the treatment of arterial thrombosis	The 83rd Annual Meeting of Japanese Society of Hematology(JSH)	Masanori Matsumoto
32	2021	Meeting Abstract	Exploring the potential of the novel IFNγ aptamer TAGX-0003 as a treatment for alopecia areata in pre-clinical models	50th Annual European Society for Dermatological Research (ESDR) Meeting	Markus Fehrholz, Kaori Harada, Ilaria Piccini, Amos Gilhar, Susumu Muto, Marta Bertolini	10.1016/j.jid.2021.08.024
31	2021	Meeting Abstract	NMR Analysis of Interaction between an ssDNA Aptamer Containing Artificial Base Ds and VEGF165	The 60th Annual Meeting of the NMR Society of Japan	Tomomi Nagahama, Tatsuhiko Someya, Susumu Muto, Taiichi Sakamoto
30	2021	Meeting Abstract	Novel IFNγ aptamer TAGX-0003 protected hair follicles from immune privilege collapse and reversed alopecia areata like phenotype in humanized mouse model.	2021 Society for Investigative Dermatology (SID) Virtual Meeting	Kaori Harada, Markus Fehrholz, Ilaria Piccini, Amos Gilhar, Marta Bertolini, Susumu Muto	10.1016/j.jid.2021.07.119
29	2020	Meeting Abstract	線維芽細胞増殖因子受容体を標的とした 人工塩基含有DNAアゴニストの開発	10th CSJ Chemistry Festa	Hayata, Yuri; Futami, Kazunobu; Ueki, Ryosuke; Sando, Shinsuke
28	2020	Meeting Abstract	Intradermal permeability of DNA aptamer through transdermal administration using Ionic Liquid	The 35th Annual Meeting of The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)	Yukari Ikeda, Yuuki Takashima, Hisako Ibaraki, Yasunori Iwao, Kaori Harada, Susumu Muto
27	2020	Meeting Abstract	Improvement of skin penetration of DNA aptamer using ionic liquid	The 36th Annual Meeting of the Japan Society of Drug Delivery System	Ikeda, Yukari; Takashima, Yuki; Ibaraki, Hisako; Iwao, Yasunori; Harada, Kaori; Muto, Susumu
26	2020	Article	Oligonucleotide aptamers: therapeutics and clinical applications	Japanese Journal of Thrombosis and Hemostasis	Akinori Mochizuki	10.2491/jjsth.31.66
25	2020	Article	Novel aptamer to von Willebrand factor A1 domain (TAGX-0004) shows total inhibition of thrombus formation superior to ARC1779 and comparable to caplacizumab	HAEMATOLOGICA	Sakai, Kazuya; Someya, Tatsuhiko; Harada, Kaori; Yagi, Hideo; Matsui, Taei; Matsumoto, Masanori	10.3324/haematol.2019.235549
24	2019	Article	Genetic Alphabet Expansion Provides Versatile Specificities and Activities of Unnatural-Base DNA Aptamers Targeting Cancer Cells	MOLECULAR THERAPY-NUCLEIC ACIDS	Futami, Kazunobu; Kimoto, Michiko; Lim, Yun Wei Shermane; Hirao, Ichiro	10.1016/j.omtn.2018.11.011
23	2018	Meeting Abstract	Inhibitory effect of novel DNA aptamer for von Willebrand factor on platelet thrombosis formation	The 80th Annual Meeting of the Japanese Society of Hematology (JSH)	Kazuya Sakai, Hideo Yagi, Masaki Hayakawa, Kaori Harada, Tatsuhiko Someya, Yoshihiro Fujimura, Masanori Matsumoto
22	2018	Meeting Abstract	New treatment modalities for thrombotic thrombocytopenic purpura	The 10th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis (APSTH)	Masanori Matsumoto
21	2018	Meeting Abstract	Inhibitory Effect of a Novel DNA Aptamer with Artificial Nucleic Bases for Von Willebrand Factor A1 Domain on Platelet Thrombosis Formation	60th American Society of Hematology (ASH) Annual Meeting and Exposition	Sakai, Kazuya; Yagi, Hideo; Hayakawa, Masaki; Someya, Tatsuhiko; Harada, Kaori; Matsumoto, Masanori	10.1182/blood-2018-99-113948
20	2017	Article	High-Affinity DNA Aptamer Generation Targeting von Willebrand Factor A1-Domain by Genetic Alphabet Expansion for Systematic Evolution of Ligands by Exponential Enrichment Using Two Types of Libraries Composed of Five Different Bases	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY	Matsunaga, Ken-ichiro; Kimoto, Michiko; Hirao, Ichiro	10.1021/jacs.6b10767
19	2016	Article	Post-ExSELEX stabilization of an unnatural-base DNA aptamer targeting VEGF(165) toward pharmaceutical applications	NUCLEIC ACIDS RESEARCH	Kimoto, Michiko; Nakamura, Mana; Hirao, Ichiro	10.1093/nar/gkw619
18	2015	Article	Architecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications	SCIENTIFIC REPORTS	Matsunaga, Ken-ichiro; Kimoto, Michiko; Hanson, Charlotte; Sanford, Michael; Young, Howard A.; Hirao, Ichiro	10.1038/srep18478
17	2015	Article	Site-specific labeling of RNA by combining genetic alphabet expansion transcription and copper-free click chemistry	NUCLEIC ACIDS RESEARCH	Someya, Tatsuhiko; Ando, Ami; Kimoto, Michiko; Hirao, Ichiro	10.1093/nar/gkv638
16	2014	Meeting Abstract	Inhibiting cytokine activity - The use of modified DNA aptamers as an alternative to neutralizing antibodies	CYTOKINE	Young, Howard A.; Hanson, Charlotte; Sanford, Michael; Matsunaga, Ken-ichiro; Kimoto, Michiko; Hirao, Ichiro	10.1016/j.cyto.2014.07.215
15	2013	Review	Site-Specific Functional Labeling of Nucleic Acids by In Vitro Replication and Transcription using Unnatural Base Pair Systems	ISRAEL JOURNAL OF CHEMISTRY	Kimoto, Michiko; Hikida, Yasushi; Hirao, Ichiro	10.1002/ijch.201300013
14	2013	Article	Generation of high-affinity DNA aptamers using an expanded genetic alphabet	NATURE BIOTECHNOLOGY	Kimoto, Michiko; Yamashige, Rie; Matsunaga, Ken-ichiro; Yokoyama, Shigeyuki; Hirao, Ichiro	10.1038/nbt.2556
13	2012	Review	Natural versus Artificial Creation of Base Pairs in DNA: Origin of Nucleobases from the Perspectives of Unnatural Base Pair Studies	ACCOUNTS OF CHEMICAL RESEARCH	Hirao, Ichiro; Kimoto, Michiko; Yamashige, Rie	10.1021/ar200257x
12	2012	Review	Unnatural base pair systems toward the expansion of the genetic alphabet in the central dogma	PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES	Hirao, Ichiro; Kimoto, Michiko	10.2183/pjab.88.345
11	2012	Article	Site-Specific Incorporation of Functional Components into RNA by an Unnatural Base Pair Transcription System	MOLECULES	Morohashi, Nobuyuki; Kimoto, Michiko; Sato, Akira; Kawai, Rie; Hirao, Ichiro	10.3390/molecules17032855
10	2012	Article	Highly specific unnatural base pair systems as a third base pair for PCR amplification	NUCLEIC ACIDS RESEARCH	Yamashige, Rie; Kimoto, Michiko; Takezawa, Yusuke; Sato, Akira; Mitsui, Tsuneo; Yokoyama, Shigeyuki; Hirao, Ichiro	10.1093/nar/gkr1068
9	2012	Article	Site-specific functionalization of RNA molecules by an unnatural base pair transcription system via click chemistry	CHEMICAL COMMUNICATIONS	Ishizuka, Takumi; Kimoto, Michiko; Sato, Akira; Hirao, Ichiro	10.1039/c2cc36293g
8	2011	Review	Unnatural base pair systems for sensing and diagnostic applications	EXPERT REVIEW OF MOLECULAR DIAGNOSTICS	Kimoto, Michiko; Cox, Robert Sidney, III; Hirao, Ichiro	10.1586/ERM.11.5
7	2011	Article	Monitoring the site-specific incorporation of dual fluorophore-quencher base analogues for target DNA detection by an unnatural base pair system	ORGANIC & BIOMOLECULAR CHEMISTRY	Yamashige, Rie; Kimoto, Michiko; Mitsui, Tsuneo; Yokoyama, Shigeyuki; Hirao, Ichiro	10.1039/c1ob06118f
6	2010	Article	A New Unnatural Base Pair System between Fluorophore and Quencher Base Analogues for Nucleic Acid-Based Imaging Technology	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY	Kimoto, Michiko; Mitsui, Tsuneo; Yamashige, Rie; Sato, Akira; Yokoyama, Shigeyuki; Hirao, Ichiro	10.1021/ja1072383
5	2010	Article	A Unique Fluorescent Base Analogue for the Expansion of the Genetic Alphabet	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY	Kimoto, Michiko; Mitsui, Tsuneo; Yokoyama, Shigeyuki; Hirao, Ichiro	10.1021/ja100806c
4	2010	Article	Site-specific fluorescent probing of RNA molecules by unnatural base-pair transcription for local structural conformation analysis	NATURE PROTOCOLS	Hikida, Yasushi; Kimoto, Michiko; Yokoyama, Shigeyuki; Hirao, Ichiro	10.1038/nprot.2010.77
3	2009	Meeting Abstract	Development of unnatural base pair systems toward new biotechnology	ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY	Hirao, Ichiro
2	2009	Meeting Abstract	Efficient PCR amplification functionalization by an unnatural base pair system	ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY	Kim, Michiko; Kawai, Rie; Mitsui, Tsuneo; Yokoyama, Shigeyuki; Hirao, Ichiro
1	2009	Article	An unnatural base pair system for efficient PCR amplification and functionalization of DNA molecules	NUCLEIC ACIDS RESEARCH	Kimoto, Michiko; Kawai, Rie; Mitsui, Tsuneo; Yokoyama, Shigeyuki; Hirao, Ichiro	10.1093/nar/gkn956